Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50282703
Substrate
n/a
Meas. Tech.
ChEMBL_35436 (CHEMBL643796)
IC50
1±n/a nM
Citation
 Glinka, TW; de Laszlo, SE; Tran, J; Chang, RS; Chen, T; Lotti, VJ; Greenlee, WJ L-161,638: A potent AT2selective quinazolinone angiotensin II binding inhibitor Bioorg Med Chem Lett 4:1479-1484 (1994)    Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2_RAT | AT2 | Agtr2 | Angiotensin II AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41346.62
Organism:
RAT
Description:
Angiotensin II AT2 0 0::P35351
Residue:
363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
  
Inhibitor
Name:
BDBM50282703
Synonyms:
CHEMBL35638 | N-Benzyl-N-{2-ethyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-quinazolin-6-yl}-isonicotinamide
Type:
Small organic molecule
Emp. Form.:
C37H30N8O2
Mol. Mass.:
618.6865
SMILES:
CCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N(Cc1ccccc1)C(=O)c1ccncc1
Structure:
Search PDB for entries with ligand similarity: