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Target
Substance-K receptor
Ligand
BDBM50050652
Substrate
n/a
Meas. Tech.
ChEBML_208851
IC50
1500±n/a nM
Citation
 Boden, P; Eden, J; Hodgson, J; Horwell, D; Pritchard, M; Raphy, J; Suman-Chauhan, N The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists Bioorg Med Chem Lett 5:1773-1778 (1995)    Article 
Target
Name:
Substance-K receptor
Synonyms:
NK2R_MESAU | Neurokinin 2 receptor | Neurokinin NK2 | TAC2R | TACR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43436.75
Organism:
HAMSTER
Description:
P51144
Residue:
384
Sequence:
MGGRAIVTDTNIFSGLESNTTGVTAFSMPAWQLALWATAYLGLVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPITKATIAGIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLVYFLPLVVMFVAYSVIGLTLWKRAVPRHQAHGANLRHLHAKKKFVKAMVLVVLTFAICWLPYHLYFILGSFQKDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTRTPSLSRRVNRCHTKETLFMTADMTHSEATNGQVGSPQDVEPAAP
  
Inhibitor
Name:
BDBM50050652
Synonyms:
CHEMBL47146 | PD-160946 | [(R)-2-(2-Fluoro-phenyl)-1-methyl-1-(7-ureido-heptylcarbamoyl)-ethyl]-carbamic acid (S)-2-methyl-1-phenyl-propyl ester
Type:
Small organic molecule
Emp. Form.:
C29H41FN4O4
Mol. Mass.:
528.6586
SMILES:
CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1
Structure:
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