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Target
Beta-mannosidase
Ligand
BDBM50070028
Substrate
n/a
Meas. Tech.
ChEBML_41367
Ki
10000±n/a nM
Citation
 Therisod, H; Letourneux, Y; Therisod, M A new strong inhibitor of beta-mannosidase. Bioorg Med Chem Lett 8:371-2 (1999) [PubMed]  Article 
Target
Name:
Beta-mannosidase
Synonyms:
Lysosomal beta A mannosidase | MANB1 | MANBA | MANBA_HUMAN | Mannanase | Mannase
Type:
PROTEIN
Mol. Mass.:
100878.33
Organism:
Homo sapiens (Human)
Description:
ChEMBL_41367
Residue:
879
Sequence:
MRLHLLLLLALCGAGTTAAELSYSLRGNWSICNGNGSLELPGAVPGCVHSALFQQGLIQDSYYRFNDLNYRWVSLDNWTYSKEFKIPFEISKWQKVNLILEGVDTVSKILFNEVTIGETDNMFNRYSFDITNVVRDVNSIELRFQSAVLYAAQQSKAHTRYQVPPDCPPLVQKGECHVNFVRKEQCSFSWDWGPSFPTQGIWKDVRIEAYNICHLNYFTFSPIYDKSAQEWNLEIESTFDVVSSKPVGGQVIVAIPKLQTQQTYSIELQPGKRIVELFVNISKNITVETWWPHGHGNQTGYNMTVLFELDGGLNIEKSAKVYFRTVELIEEPIKGSPGLSFYFKINGFPIFLKGSNWIPADSFQDRVTSELLRLLLQSVVDANMNTLRVWGGGIYEQDEFYELCDELGIMVWQDFMFACALYPTDQGFLDSVTAEVAYQIKRLKSHPSIIIWSGNNENEEALMMNWYHISFTDRPIYIKDYVTLYVKNIRELVLAGDKSRPFITSSPTNGAETVAEAWVSQNPNSNYFGDVHFYDYISDCWNWKVFPKARFASEYGYQSWPSFSTLEKVSSTEDWSFNSKFSLHRQHHEGGNKQMLYQAGLHFKLPQSTDPLRTFKDTIYLTQVMQAQCVKTETEFYRRSRSEIVDQQGHTMGALYWQLNDIWQAPSWASLEYGGKWKMLHYFAQNFFAPLLPVGFENENTFYIYGVSDLHSDYSMTLSVRVHTWSSLEPVCSRVTERFVMKGGEAVCLYEEPVSELLRRCGNCTRESCVVSFYLSADHELLSPTNYHFLSSPKEAVGLCKAQITAIISQQGDIFVFDLETSAVAPFVWLDVGSIPGRFSDNGFLMTEKTRTILFYPWEPTSKNELEQSFHVTSLTDIY
  
Inhibitor
Name:
BDBM50070028
Synonyms:
3,4,5-Trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-one O-(2,4-dinitro-phenyl)-oxime | CHEMBL62534
Type:
Small organic molecule
Emp. Form.:
C12H13N3O10
Mol. Mass.:
359.2457
SMILES:
OCC1[O+]=C([N-]Oc2ccc(cc2[N+]([O-])=O)[N+]([O-])=O)C(O)C(O)C1O |t:3|
Structure:
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