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Target
Calpain-1 catalytic subunit
Ligand
BDBM50080206
Substrate
n/a
Meas. Tech.
ChEMBL_43488 (CHEMBL657761)
Ki
33±n/a nM
Citation
 Peet, NP; Kim, HO; Marquart, AL; Angelastro, MR; Nieduzak, TR; White, JN; Friedrich, D; Flynn, GA; Webster, ME; Vaz, RJ; Linnik, MD; Koehl, JR; Mehdi, S; Bey, P; Emary, B; Hwang, KK Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain. Bioorg Med Chem Lett 9:2365-70 (1999) [PubMed]  Article 
Target
Name:
Calpain-1 catalytic subunit
Synonyms:
CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1
Type:
Protein
Mol. Mass.:
81880.51
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
714
Sequence:
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
  
Inhibitor
Name:
BDBM50080206
Synonyms:
CHEMBL311735 | [1-((4S,5R)-4-Benzyl-5-hydroxy-oxazolidine-3-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C23H28N2O5
Mol. Mass.:
412.4788
SMILES:
CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CO[C@@H](O)[C@@H]1Cc1ccccc1
Structure:
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