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Target
Cathepsin B
Ligand
BDBM50080206
Substrate
n/a
Meas. Tech.
ChEMBL_47387 (CHEMBL872428)
Ki
120±n/a nM
Citation
 Peet, NP; Kim, HO; Marquart, AL; Angelastro, MR; Nieduzak, TR; White, JN; Friedrich, D; Flynn, GA; Webster, ME; Vaz, RJ; Linnik, MD; Koehl, JR; Mehdi, S; Bey, P; Emary, B; Hwang, KK Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain. Bioorg Med Chem Lett 9:2365-70 (1999) [PubMed]  Article 
Target
Name:
Cathepsin B
Synonyms:
BCSB | CATB_BOVIN | CTSB | Cathepsin B precursor | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
36657.87
Organism:
Bos taurus (bovine)
Description:
Bovine spleen CB was purchased from Sigma Co. (USA).
Residue:
335
Sequence:
MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY
  
Inhibitor
Name:
BDBM50080206
Synonyms:
CHEMBL311735 | [1-((4S,5R)-4-Benzyl-5-hydroxy-oxazolidine-3-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester
Type:
Small organic molecule
Emp. Form.:
C23H28N2O5
Mol. Mass.:
412.4788
SMILES:
CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CO[C@@H](O)[C@@H]1Cc1ccccc1
Structure:
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