Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50083976
Substrate
n/a
Meas. Tech.
ChEBML_70348
IC50
960±n/a nM
Citation
 Ye, Z; Gao, Y; Bakshi, RK; Chen, MH; Rohrer, SP; Feighner, SD; Pong, SS; Howard, AD; Blake, A; Birzin, ET; Locco, L; Parmar, RM; Chan, WW; Schaeffer, JM; Smith, RG; Patchett, AA; Nargund, RP Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues. Bioorg Med Chem Lett 10:5-8 (2000) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Homo sapiens (Human)
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50083976
Synonyms:
CHEMBL536779 | N-(6-Amino-hexyl)-2-(6-bromo-2-naphthalen-2-yl-4-oxo-4H-quinazolin-3-yl)-acetamide; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C26H27BrN4O2
Mol. Mass.:
507.422
SMILES:
NCCCCCCNC(=O)Cn1c(nc2ccc(Br)cc2c1=O)-c1ccc2ccccc2c1
Structure:
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