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Target
Collagenase 3
Ligand
BDBM50095215
Substrate
n/a
Meas. Tech.
ChEBML_106604
IC50
2000±n/a nM
Citation
 Barta, TE; Becker, DP; Bedell, LJ; De Crescenzo, GA; McDonald, JJ; Munie, GE; Rao, S; Shieh, HS; Stegeman, R; Stevens, AM; Villamil, CI Synthesis and activity of selective MMP inhibitors with an aryl backbone. Bioorg Med Chem Lett 10:2815-7 (2000) [PubMed]  Article 
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM50095215
Synonyms:
CHEMBL330078 | N-Hydroxy-2-[3-(4-trifluoromethyl-phenoxy)-pyrrolidine-1-sulfonyl]-benzamide
Type:
Small organic molecule
Emp. Form.:
C18H17F3N2O5S
Mol. Mass.:
430.398
SMILES:
ONC(=O)c1ccccc1S(=O)(=O)N1CCC(C1)Oc1ccc(cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: