Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50087247
Substrate
n/a
Meas. Tech.
ChEBML_45274
Ki
0.600000±n/a nM
Citation
 Renzi, G; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: topical sulfonamide antiglaucoma agents incorporating secondary amine moieties. Bioorg Med Chem Lett 10:673-6 (2000) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
  
Inhibitor
Name:
BDBM50087247
Synonyms:
5-{4-[(7-Chloro-2-oxo-2H-chromen-4-ylmethyl)-amino]-benzenesulfonylamino}-[1,3,4]thiadiazole-2-sulfonic acid amide | CHEMBL158693
Type:
Small organic molecule
Emp. Form.:
C19H16ClN5O6S3
Mol. Mass.:
542.008
SMILES:
Cn1nc(s\c1=N/S(=O)(=O)c1ccc(NCc2cc(=O)oc3cc(Cl)ccc23)cc1)S(N)(=O)=O
Structure:
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