Reaction Details Report a problem with these data
Target
Collagenase 3
Ligand
BDBM50098924
Substrate
n/a
Meas. Tech.
ChEBML_106619
IC50
0.750000±n/a nM
Citation
Pikul, S; Dunham, KM; Almstead, NG; De, B; Natchus, MG; Taiwo, YO; Williams, LE; Hynd, BA; Hsieh, LC; Janusz, MJ; Gu, F; Mieling, GE Heterocycle-based MMP inhibitors with P2' substituents. Bioorg Med Chem Lett 11:1009-13 (2001) [PubMed] Article
More Info.:
Target
Name:
Collagenase 3
Synonyms:
Collagenase 3 | MMP-13 | MMP13_RAT | Matrix metalloproteinase 13 | Matrix metalloproteinase-13 | Mmp13 | UMRCASE
Type:
PROTEIN
Mol. Mass.:
53359.23
Organism:
Rattus norvegicus
Description:
ChEMBL_424298
Residue:
466
Sequence:
ATFFLLSWTHCWSLPLPYGDDDDDDLSEEDLEFAEHYLKSYYHPVTLAGILKKSTVTSTVDRLREMQSFFGLDVTGKLDDPTLDIMRKPRCGVPDVGVYNVFPRTLKWSQTNLTYRIVNYTPDISHSEVEKAFRKAFKVWSDVTPLNFTRIHDGTADIMISFGTKEHGDFYPFDGPSGLLAHAFPPGPNLGGDAHFDDDETWTSSSKGYNLFIVAAHELGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPEKCDPALSLDAITSLRGETMIFKDRFFWRLHPQQVEPELFLTKSFWPELPNHVDAAYEHPSRDLMFIFRGRKFWALNGYDIMEGYPRKISDLGFPKEVKRLSAAVHFEDTGKTLFFSGNHVWSYDDANQTMDKDYPRLIEEEFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPTNSLLWC
Inhibitor
Name:
BDBM50098924
Synonyms:
(R)-1-Cyclohexyl-3-(4-methoxy-benzenesulfonyl)-6-oxo-hexahydro-pyrimidine-4-carboxylic acid hydroxyamide | CHEMBL269019
Type:
Small organic molecule
Emp. Form.:
C18H25N3O6S
Mol. Mass.:
411.473
SMILES:
COc1ccc(cc1)S(=O)(=O)N1CN(C2CCCCC2)C(=O)C[C@@H]1C(=O)NO