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Target
Methionine--tRNA ligase, cytoplasmic
Ligand
BDBM50099113
Substrate
n/a
Meas. Tech.
ChEBML_67947
IC50
163500±n/a nM
Citation
 Lee, J; Kang, SU; Kim, SY; Kim, SE; Job, YJ; Kim, S Vanilloid and isovanilloid analogues as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases. Bioorg Med Chem Lett 11:965-8 (2001) [PubMed]  Article 
Target
Name:
Methionine--tRNA ligase, cytoplasmic
Synonyms:
MARS | MARS1 | Methionyl-tRNA synthetase | SYMC_HUMAN
Type:
PROTEIN
Mol. Mass.:
101110.04
Organism:
Homo sapiens (Human)
Description:
ChEMBL_105283
Residue:
900
Sequence:
MRLFVSDGVPGCLPVLAAAGRARGRAEVLISTVGPEDCVVPFLTRPKVPVLQLDSGNYLFSTSAICRYFFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVVQGKKGEDVLGSVRRALTHIDHSLSRQNCPFLAGETESLADIVLWGALYPLLQDPAYLPEELSALHSWFQTLSTQEPCQRAAETVLKQQGVLALRPYLQKQPQPSPAEGRAVTNEPEEEELATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYVNNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEEGLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLKRGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLINAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWTPNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGYLSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNYTLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIRPEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLTPDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAKTSPKPAVVETVTTAKPQQIQALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGKPPEAPKGKKKK
  
Inhibitor
Name:
BDBM50099113
Synonyms:
(S)-1-{2-[2-(3-Hydroxy-4-methoxy-phenyl)-acetylamino]-ethoxycarbonyl}-3-methylsulfanyl-propyl-ammonium
Type:
Small organic molecule
Emp. Form.:
C16H25N2O5S
Mol. Mass.:
357.445
SMILES:
COc1ccc(CC(=O)NCCOC(=O)[C@@H]([NH3+])CCSC)cc1O
Structure:
Search PDB for entries with ligand similarity: