Reaction Details Report a problem with these data
Target
Estrogen receptor beta
Ligand
BDBM50144774
Substrate
n/a
Meas. Tech.
ChEBML_67682
IC50
1700±n/a nM
Citation
 Yang, W; Wang, Y; Ma, Z; Golla, R; Stouch, T; Seethala, R; Johnson, S; Zhou, R; Güngör, T; Feyen, JH; Dickson, JK Synthesis and structure-activity relationship of 3-arylbenzoxazines as selective estrogen receptor beta agonists. Bioorg Med Chem Lett 14:2327-30 (2004) [PubMed]  Article 
Target
Name:
Estrogen receptor beta
Synonyms:
ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta
Type:
Protein
Mol. Mass.:
59238.43
Organism:
Homo sapiens (Human)
Description:
Q92731
Residue:
530
Sequence:
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
  
Inhibitor
Name:
BDBM50144774
Synonyms:
3-(3-Bromo-4-hydroxy-phenyl)-2,2-dimethyl-2H-benzo[1,4]oxazine-5,7-diol | CHEMBL74027
Type:
Small organic molecule
Emp. Form.:
C16H14BrNO4
Mol. Mass.:
364.191
SMILES:
CC1(C)Oc2cc(O)cc(O)c2N=C1c1ccc(O)c(Br)c1 |c:13|
Structure:
Search PDB for entries with ligand similarity: