Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50022406
Substrate
n/a
Meas. Tech.
ChEBML_31633
IC50
10000±n/a nM
Citation
 Sarges, R; Schnur, RC; Belletire, JL; Peterson, MJ Spiro hydantoin aldose reductase inhibitors. J Med Chem 31:230-43 (1988) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50022406
Synonyms:
6-chlorospiro[3,4-dihydro-2H-chromene-4,4'-(tetrahydro-1'H-imidazole)]-2'-one1/2H2O | CHEMBL78821
Type:
Small organic molecule
Emp. Form.:
C11H11ClN2O2
Mol. Mass.:
238.67
SMILES:
Clc1ccc2OCCC3(CNC(=O)N3)c2c1
Structure:
Search PDB for entries with ligand similarity: