Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50017234
Substrate
n/a
Meas. Tech.
ChEBML_201290
Ki
410±n/a nM
Citation
 Hutchison, AJ; de Jesus, R; Williams, M; Simke, JP; Neale, RF; Jackson, RH; Ambrose, F; Barbaz, BJ; Sills, MA Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity. J Med Chem 32:2221-6 (1989) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor, sigma 1 | Oprs1 | SGMR1_MOUSE | Sigma 1-type opioid receptor | Sigma1-receptor | Sigma1R | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25246.51
Organism:
Mus musculus (Mouse)
Description:
O55242
Residue:
223
Sequence:
MPWAAGRRWAWITLILTIIAVLIQAAWLWLGTQNFVFSREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCILHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWKEGTTKSEVFYPGETVVHGPGEATALEWGPNTWMVEYGRGVIPSTLFFALADTFFSTQDYLTLFYTLRAYARGLRLELTTYLFGQDS
  
Inhibitor
Name:
BDBM50017234
Synonyms:
(4aS,9aR)-2-Cyclobutylmethyl-4a-ethyl-1,2,3,4,4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridin-6-ol; hydrochloride | CHEMBL542150
Type:
Small organic molecule
Emp. Form.:
C18H25NO2
Mol. Mass.:
287.3966
SMILES:
CC[C@@]12CCN(CC3CCC3)C[C@@H]1Oc1ccc(O)cc21
Structure:
Search PDB for entries with ligand similarity: