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Target
Thymidine kinase, cytosolic
Ligand
BDBM50013115
Substrate
n/a
Meas. Tech.
ChEMBL_208193 (CHEMBL819096)
Ki
445000±n/a nM
Citation
 Palomino, E; Meltsner, BR; Kessel, D; Horwitz, JP Synthesis and in vitro evaluation of some modified 4-thiopyrimidine nucleosides for prevention or reversal of AIDS-associated neurological disorders. J Med Chem 33:258-63 (1990) [PubMed]  Article 
Target
Name:
Thymidine kinase, cytosolic
Synonyms:
KITH_HUMAN | TK1
Type:
PROTEIN
Mol. Mass.:
25476.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1333884
Residue:
234
Sequence:
MSCINLPTVLPGSPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSSSFCTHDRNTMEALPACLLRDVAQEALGVAVIGIDEGQFFPDIVEFCEAMANAGKTVIVAALDGTFQRKPFGAILNLVPLAESVVKLTAVCMECFREAAYTKRLGTEKEVEVIGGADKYHSVCRLCYFKKASGQPAGPDNKENCPVPGKPGEAVAARKLFAPQQILQCSPAN
  
Inhibitor
Name:
BDBM50013115
Synonyms:
1-((2R,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 1-(5-Hydroxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione (ddeUrd) | CHEMBL89637
Type:
Small organic molecule
Emp. Form.:
C9H10N2O4
Mol. Mass.:
210.1867
SMILES:
OC[C@H]1O[C@H](C=C1)n1ccc(=O)[nH]c1=O |c:5|
Structure:
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