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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50014247
Substrate
n/a
Meas. Tech.
ChEBML_131452
Ki
120±n/a nM
Citation
 Maryanoff, BE; Vaught, JL; Shank, RP; McComsey, DF; Costanzo, MJ; Nortey, SO Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J Med Chem 33:2793-7 (1990) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Norepinephrine transporter | SC6A2_MOUSE | Slc6a2 | Sodium-dependent noradrenaline transporter
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69260.85
Organism:
MOUSE
Description:
Norepinephrine transporter 0 MOUSE::O55192
Residue:
617
Sequence:
MLLARMNPQVQPELGGADPLPEQPLRPCKTADLLVVKERNGVQCLLASQDSDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCVVTISTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYTYPPWANWVGWGIALSSMILVPAYVIYKFLSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI
  
Inhibitor
Name:
BDBM50014247
Synonyms:
(3R,4S)-3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine | 3-(4-Methoxy-phenoxymethyl)-1-methyl-4-phenyl-piperidine(femoxetine) | CHEMBL94739 | Femoxetine
Type:
Small organic molecule
Emp. Form.:
C20H25NO2
Mol. Mass.:
311.418
SMILES:
COc1ccc(OC[C@H]2CN(C)CC[C@@H]2c2ccccc2)cc1
Structure:
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