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Target
Tubulin beta-2B chain
Ligand
BDBM50014850
Substrate
n/a
Meas. Tech.
ChEBML_211651
IC50
2300±n/a nM
Citation
 Muzaffar, A; Brossi, A; Lin, CM; Hamel, E Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J Med Chem 33:567-71 (1990) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50014850
Synonyms:
CHEMBL156889 | N-(3-Hydroxy-1,2-dimethoxy-10-methylamino-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C21H24N2O5
Mol. Mass.:
384.4257
SMILES:
CNc1ccc2-c3c(CC[C@H](NC(C)=O)c2cc1=O)cc(O)c(OC)c3OC
Structure:
Search PDB for entries with ligand similarity: