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Target
Tubulin beta-2B chain
Ligand
BDBM50014873
Substrate
n/a
Meas. Tech.
ChEBML_211651
IC50
2100±n/a nM
Citation
 Muzaffar, A; Brossi, A; Lin, CM; Hamel, E Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J Med Chem 33:567-71 (1990) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50014873
Synonyms:
(-)-cornigerine | 1N-[3,13-dimethoxy-4-oxo-(6S)-4,6,7,8-tetrahydroheptaleno[1',2':4,5]benzo[d][1,3]dioxol-6-yl]acetamide(cornigerine) | 1N-[3,13-dimethoxy-4-oxo-(6S)-4,6,7,8-tetrahydroheptaleno[2',1':4,5]benzo[d][1,3]dioxol-6-yl]acetamide (Cornigerine) | CHEMBL282984
Type:
Small organic molecule
Emp. Form.:
C21H21NO6
Mol. Mass.:
383.3945
SMILES:
COc1c2OCOc2cc2CC[C@H](NC(C)=O)c3cc(=O)c(OC)ccc3-c12 |r|
Structure:
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