Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50005979
Substrate
n/a
Meas. Tech.
ChEBML_28336
IC50
43±n/a nM
Citation
 Roark, WH; Roth, BD; Holmes, A; Trivedi, BK; Kieft, KA; Essenburg, AD; Krause, BR; Stanfield, RL Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond. J Med Chem 36:1662-8 (1993) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50005979
Synonyms:
CHEMBL46510 | Octadec-9-enoic acid (2,6-dimethyl-phenyl)-amide
Type:
Small organic molecule
Emp. Form.:
C26H43NO
Mol. Mass.:
385.6257
SMILES:
CCCCCCCC\C=C/CCCCCCCC(=O)Nc1c(C)cccc1C
Structure:
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