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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50047667
Substrate
n/a
Meas. Tech.
ChEBML_28336
IC50
4700±n/a nM
Citation
 Roark, WH; Roth, BD; Holmes, A; Trivedi, BK; Kieft, KA; Essenburg, AD; Krause, BR; Stanfield, RL Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond. J Med Chem 36:1662-8 (1993) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50047667
Synonyms:
1-(2,4-Difluoro-phenyl)-3-octadec-9-enyl-urea | CHEMBL297460
Type:
Small organic molecule
Emp. Form.:
C25H40F2N2O
Mol. Mass.:
422.5947
SMILES:
CCCCCCCC\C=C/CCCCCCCCNC(=O)Nc1ccc(F)cc1F
Structure:
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