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Target
Tubulin beta-2B chain
Ligand
BDBM50044960
Substrate
n/a
Meas. Tech.
ChEMBL_211332 (CHEMBL820775)
IC50
3400±n/a nM
Citation
 Kuo, SC; Lee, HZ; Juang, JP; Lin, YT; Wu, TS; Chang, JJ; Lednicer, D; Paull, KD; Lin, CM; Hamel, E Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin. J Med Chem 36:1146-56 (1993) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50044960
Synonyms:
7-Hydroxy-2-phenyl-1H-quinolin-4-one | CHEMBL15634
Type:
Small organic molecule
Emp. Form.:
C15H11NO2
Mol. Mass.:
237.2533
SMILES:
Oc1ccc2c(O)cc(nc2c1)-c1ccccc1
Structure:
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