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Target
Protein kinase C gamma type
Ligand
BDBM50043774
Substrate
n/a
Meas. Tech.
ChEMBL_161143 (CHEMBL767411)
IC50
50000±n/a nM
Citation
 Kashiwada, Y; Huang, L; Ballas, LM; Jiang, JB; Janzen, WP; Lee, KH New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem 37:195-200 (1994) [PubMed]  Article 
Target
Name:
Protein kinase C gamma type
Synonyms:
KPCG_HUMAN | PKC gamma | PKC-gamma | PKCG | PRKCG | Protein kinase C gamma | Protein kinase C gamma type | Protein kinase C, PKC; classical/novel | Protein kinase C, gamma
Type:
Enzyme
Mol. Mass.:
78458.05
Organism:
Homo sapiens (Human)
Description:
The recombinant human PKC enzymes were produced using a baculovirus expression system in SF9 cells
Residue:
697
Sequence:
MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM
  
Inhibitor
Name:
BDBM50043774
Synonyms:
6,6'-Bis-methoxymethyl-biphenyl-2,3,4,2',3',4'-hexaol | CHEMBL59451
Type:
Small organic molecule
Emp. Form.:
C16H18O8
Mol. Mass.:
338.3093
SMILES:
COCc1cc(O)c(O)c(O)c1-c1c(O)c(O)c(O)cc1COC |(6.66,-8.73,;5.33,-7.94,;4,-8.73,;2.66,-7.96,;2.66,-6.42,;1.31,-5.65,;1.31,-4.11,;-.02,-6.42,;-1.07,-5.54,;-.02,-7.96,;-1.35,-8.73,;1.31,-8.73,;1.31,-10.27,;-.02,-11.04,;-1.35,-10.27,;-.02,-12.58,;-1.35,-13.35,;1.31,-13.35,;1.33,-14.89,;2.66,-12.56,;2.66,-11.04,;3.97,-10.25,;5.33,-11.02,;6.66,-10.25,)|
Structure:
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