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Target
Mu-type opioid receptor
Ligand
BDBM50039661
Substrate
n/a
Meas. Tech.
ChEMBL_138893 (CHEMBL747885)
Ki
31±n/a nM
Citation
 Zuckermann, RN; Martin, EJ; Spellmeyer, DC; Stauber, GB; Shoemaker, KR; Kerr, JM; Figliozzi, GM; Goff, DA; Siani, MA; Simon, RJ Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library. J Med Chem 37:2678-85 (1994) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50039661
Synonyms:
CHEMBL327549 | CHIR-4537 | N-({Carbamoylmethyl-[2-(4-hydroxy-phenyl)-ethyl]-carbamoyl}-methyl)-N-(3,4-dimethoxy-benzyl)-2-(2,2-diphenyl-ethylamino)-acetamide
Type:
Small organic molecule
Emp. Form.:
C37H42N4O6
Mol. Mass.:
638.7526
SMILES:
COc1ccc(CN(CC(=O)N(CCc2ccc(O)cc2)CC(N)=O)C(=O)CNCC(c2ccccc2)c2ccccc2)cc1OC
Structure:
Search PDB for entries with ligand similarity: