Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50039665
Substrate
n/a
Meas. Tech.
ChEMBL_138893 (CHEMBL747885)
Ki
6±n/a nM
Citation
Zuckermann, RN; Martin, EJ; Spellmeyer, DC; Stauber, GB; Shoemaker, KR; Kerr, JM; Figliozzi, GM; Goff, DA; Siani, MA; Simon, RJ Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library. J Med Chem 37:2678-85 (1994) [PubMed] Article
More Info.:
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
Inhibitor
Name:
BDBM50039665
Synonyms:
CHEMBL90649 | CHIR-4531 | N-Benzo[1,3]dioxol-5-ylmethyl-N-({carbamoylmethyl-[2-(4-hydroxy-phenyl)-ethyl]-carbamoyl}-methyl)-2-(2,2-diphenyl-ethylamino)-acetamide
Type:
Small organic molecule
Emp. Form.:
C36H38N4O6
Mol. Mass.:
622.7101
SMILES:
NC(=O)CN(CCc1ccc(O)cc1)C(=O)CN(Cc1ccc2OCOc2c1)C(=O)CNCC(c1ccccc1)c1ccccc1