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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50040780
Substrate
n/a
Meas. Tech.
ChEMBL_32090 (CHEMBL643666)
IC50
3500±n/a nM
Citation
 Lee, YS; Pearlstein, R; Kador, PF Molecular modeling studies of aldose reductase inhibitors. J Med Chem 37:787-92 (1994) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50040780
Synonyms:
CHEMBL163958 | cid_234512 | spiro[9H-fluorene-9,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione
Type:
Small organic molecule
Emp. Form.:
C15H10N2O2
Mol. Mass.:
250.2521
SMILES:
O=C1NC(=O)C2(N1)c1ccccc1-c1ccccc21
Structure:
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