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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50040782
Substrate
n/a
Meas. Tech.
ChEMBL_32090 (CHEMBL643666)
IC50
130±n/a nM
Citation
 Lee, YS; Pearlstein, R; Kador, PF Molecular modeling studies of aldose reductase inhibitors. J Med Chem 37:787-92 (1994) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50040782
Synonyms:
(2,8-Diisopropyl-3-thioxo-2,3-dihydro-benzo[1,4]oxazin-4-yl)-acetic acid | CHEMBL164603
Type:
Small organic molecule
Emp. Form.:
C16H21NO3S
Mol. Mass.:
307.408
SMILES:
CC(C)C1Oc2c(cccc2N(CC(O)=O)C1=S)C(C)C
Structure:
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