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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50048871
Substrate
n/a
Meas. Tech.
ChEMBL_201746 (CHEMBL809880)
Ki
47±n/a nM
Citation
 Berardi, F; Colabufo, NA; Giudice, G; Perrone, R; Tortorella, V; Govoni, S; Lucchi, L New sigma and 5-HT1A receptor ligands: omega-(tetralin-1-yl)-n-alkylamine derivatives. J Med Chem 39:176-82 (1996) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50048871
Synonyms:
1-[4-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-butyl]-4-(3,4,5,6-tetrahydro-pyridin-2-yl)-piperazine | CHEMBL50239
Type:
Small organic molecule
Emp. Form.:
C24H37N3O
Mol. Mass.:
383.5701
SMILES:
COc1cccc2C(CCCCN3CCN(CC3)C3=NCCCC3)CCCc12 |t:19|
Structure:
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