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Target
Leukotriene B4 receptor 1
Ligand
BDBM50000541
Substrate
n/a
Meas. Tech.
ChEMBL_99847 (CHEMBL706765)
IC50
420±n/a nM
Citation
 Hibi, S; Okamoto, Y; Tagami, K; Numata, H; Kobayashi, N; Shinoda, M; Kawahara, T; Harada, K; Miyamoto, K; Yamatsu, I Structure-activity relationships of (E)-3-(1,4-benzoquinonyl)-2-[(3-pyridyl)-alkyl]-2-propenoic acid derivatives that inhibit both 5-lipoxygenase and thromboxane A2 synthetase. J Med Chem 39:3148-57 (1996) [PubMed]  Article 
Target
Name:
Leukotriene B4 receptor 1
Synonyms:
BLT | BLT1 | BLTR | CMKRL1 | Chemoattractant receptor-like 1 | G-protein coupled receptor 16 | GPR16 | LT4R1_HUMAN | LTB4-R 1 | LTB4R | Leukotriene B4 R1 | Leukotriene B4 receptor | Leukotriene B4 receptor 1 | P2RY7 | P2Y purinoceptor 7 | P2Y7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37582.68
Organism:
Homo sapiens (Human)
Description:
Q15722
Residue:
352
Sequence:
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
  
Inhibitor
Name:
BDBM50000541
Synonyms:
(+-)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea | 1-[1-(1-benzothien-2-yl)ethyl]-1-hydroxyurea | CHEMBL93 | Leutrol | N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyurea | N-[1-(benzo[b]thiophen-2-yl)ethyl]-N-hydroxyurea | ZILEUTON | Zyflo (TN)
Type:
Small organic molecule
Emp. Form.:
C11H12N2O2S
Mol. Mass.:
236.29
SMILES:
CC(N(O)C(N)=O)c1cc2ccccc2s1
Structure:
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