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Target
Translocator protein
Ligand
BDBM50059758
Substrate
n/a
Meas. Tech.
ChEMBL_37036 (CHEMBL650832)
IC50
3.1±n/a nM
Citation
 Cappelli, A; Anzini, M; Vomero, S; De Benedetti, PG; Menziani, MC; Giorgi, G; Manzoni, C Mapping the peripheral benzodiazepine receptor binding site by conformationally restrained derivatives of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3- isoquinolinecarboxamide (PK11195). J Med Chem 40:2910-21 (1997) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50059758
Synonyms:
4-Methyl-1-phenyl-isoquinoline-3-carboxylic acid benzyl-methyl-amide | CHEMBL280482
Type:
Small organic molecule
Emp. Form.:
C25H22N2O
Mol. Mass.:
366.455
SMILES:
CN(Cc1ccccc1)C(=O)c1nc(-c2ccccc2)c2ccccc2c1C
Structure:
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