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Target
Nitric oxide synthase, inducible
Ligand
BDBM50225106
Substrate
n/a
Meas. Tech.
ChEMBL_89190 (CHEMBL700508)
IC50
7600±n/a nM
Citation
 Hagen, TJ; Bergmanis, AA; Kramer, SW; Fok, KF; Schmelzer, AE; Pitzele, BS; Swenton, L; Jerome, GM; Kornmeier, CM; Moore, WM; Branson, LF; Connor, JR; Manning, PT; Currie, MG; Hallinan, EA 2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase. J Med Chem 41:3675-83 (1998) [PubMed]  Article 
Target
Name:
Nitric oxide synthase, inducible
Synonyms:
HEP-NOS | Hepatocyte NOS | Inducible NO synthase | Inducible NOS | NOS type II | NOS2 | NOS2A | NOS2_HUMAN | Nitric oxide synthase, inducible (iNOS) | iNOS
Type:
Homodimer
Mol. Mass.:
131141.95
Organism:
Homo sapiens (Human)
Description:
P35228
Residue:
1153
Sequence:
MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDRVAVQPSSLEMSAL
  
Inhibitor
Name:
BDBM50225106
Synonyms:
(2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino}pentanoic acid | (2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino}pentanoic acid]] | (2S)-2-amino-5-{[(E)-imino(nitroamino)methyl]amino}pentanoic acid | (2S)-2-amino-5-{[imino(nitroamino)methyl]amino}pentanoic acid | (S)-2-Amino-5-(N'-nitro-guanidino)-pentanoic acid | 2-Amino-5-(N'-nitro-guanidino)-pentanoic acid | CHEMBL227744 | N-OMEGA-NITRO-L-ARGININE | N-nitro-L-arginine | NG-nitroarginine | Ngamma-nitro-L-arginine | Nomega-nitro-L-arginine
Type:
Small organic molecule
Emp. Form.:
C6H13N5O4
Mol. Mass.:
219.1985
SMILES:
N[C@@H](CCCNC(N)=N[N+]([O-])=O)C(O)=O |r,w:8.8|
Structure:
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