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Target
Melatonin receptor type 1A
Ligand
BDBM50086006
Substrate
n/a
Meas. Tech.
ChEMBL_105101 (CHEMBL715945)
Ki
437±n/a nM
Citation
 Faust, R; Garratt, PJ; Jones, R; Yeh, LK; Tsotinis, A; Panoussopoulou, M; Calogeropoulou, T; Teh, MT; Sugden, D Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles. J Med Chem 43:1050-61 (2000) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50086006
Synonyms:
CHEMBL276490 | Cyclobutanecarboxylic acid [2-(10-methoxy-5,6-dihydro-indolo[2,1-a]isoquinolin-12-yl)-ethyl]-amide
Type:
Small organic molecule
Emp. Form.:
C24H26N2O2
Mol. Mass.:
374.4754
SMILES:
COc1ccc2n3CCc4ccccc4-c3c(CCNC(=O)C3CCC3)c2c1
Structure:
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