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Target
Kappa-type opioid receptor
Ligand
BDBM50102814
Substrate
n/a
Meas. Tech.
ChEMBL_146235 (CHEMBL755003)
Ki
>1000±n/a nM
Citation
 Soukara, S; Maier, CA; Predoiu, U; Ehret, A; Jackisch, R; Wünsch, B Methylated analogues of methyl (R)-4-(3,4-dichlorophenylacetyl)- 3-(pyrrolidin-1-ylmethyl)piperazine-1-carboxylate (GR-89,696) as highly potent kappa-receptor agonists: stereoselective synthesis, opioid-receptor affinity, receptor selectivity, and functional studies. J Med Chem 44:2814-26 (2001) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50102814
Synonyms:
2-(3,4-Dichloro-phenyl)-1-[4-phenyl-2-(1-pyrrolidin-1-yl-ethyl)-piperazin-1-yl]-ethanone | CHEMBL97590
Type:
Small organic molecule
Emp. Form.:
C24H29Cl2N3O
Mol. Mass.:
446.413
SMILES:
C[C@H](C1CN(CCN1C(=O)Cc1ccc(Cl)c(Cl)c1)c1ccccc1)N1CCCC1
Structure:
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