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Target
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50116432
Substrate
n/a
Meas. Tech.
ChEMBL_205035 (CHEMBL812394)
IC50
410±n/a nM
Citation
 Picard, F; Barassin, S; Mokhtarian, A; Hartmann, RW Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-N-acylpiperidines: highly potent and in vivo active steroid 5alpha-reductase type 2 inhibitors. J Med Chem 45:3406-17 (2002) [PubMed]  Article 
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
  
Inhibitor
Name:
BDBM50116432
Synonyms:
4-(1-Diphenylacetyl-piperidin-4-ylidenemethyl)-3-fluoro-benzoic acid | CHEMBL117881
Type:
Small organic molecule
Emp. Form.:
C27H24FNO3
Mol. Mass.:
429.4828
SMILES:
[#8]-[#6](=O)-c1ccc(\[#6]=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6](-c2ccccc2)-c2ccccc2)c(F)c1
Structure:
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