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Target
Poly(ADP-ribose) glycohydrolase
Ligand
BDBM50370276
Substrate
n/a
Meas. Tech.
ChEMBL_159833 (CHEMBL763201)
IC50
3070±n/a nM
Citation
 Koh, DW; Coyle, DL; Mehta, N; Ramsinghani, S; Kim, H; Slama, JT; Jacobson, MK SAR analysis of adenosine diphosphate (hydroxymethyl)pyrrolidinediol inhibition of poly(ADP-ribose) glycohydrolase. J Med Chem 46:4322-32 (2003) [PubMed]  Article 
Target
Name:
Poly(ADP-ribose) glycohydrolase
Synonyms:
PARG | PARG_BOVIN | Poly [ADP-ribose] glycohydrolase
Type:
PROTEIN
Mol. Mass.:
110843.68
Organism:
Bos taurus
Description:
ChEMBL_159835
Residue:
977
Sequence:
MSAGPGCEPCTKRPRWDAAATSPPAASDARSFPGRQRRVLDSKDAPVQFRVPPSSSGCALGRAGQHRGSATSLVFKQKTITSWMDTKGIKTVESESLHSKENNNTREESMMSSVQKDNFYQHNMEKLENVSQLGFDKSPVEKGTQYLKQHQTAAMCKWQNEGPHSERLLESEPPAVTLVPEQFSNANVDQSSPKDDHSDTNSEESRDNQQFLTHVKLANAKQTMEDEQGREARSHQKCGKACHPAEACAGCQQEETDVVSESPLSDTGSEDVGTGLKNANRLNRQESSLGNSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPGFDEQEDSSSAQTANKPSRFQPREADTELRKRSSAKGGEIRLHFQFEGGESRAGMNDVNAKRPGSTSSLNVECRNSKQHGRKDSKITDHFMRVPKAEDKRKEQCEMKHQRTERKIPKYIPPHLSPDKKWLGTPIEEMRRMPRCGIRLPPLRPSANHTVTIRVDLLRIGEVPKPFPTHFKDLWDNKHVKMPCSEQNLYPVEDENGERAAGSRWELIQTALLNRLTRPQNLKDAILKYNVAYSKKWDFTALIDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSITMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCEKLLTRLHVTYEGTIEGNGQGMLQVDFANRFVGGGVTSAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSHEDRSERDDWQRRTTEIVAIDALHFRRYLDQFVPEKIRRELNKAYCGFLRPGVSSENLSAVATGNWGCGAFGGDARLKALIQILAAAVAERDVVYFTFGDSELMRDIYSMHTFLTERKLTVGEVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESCTQTTNQPGQRTGA
  
Inhibitor
Name:
BDBM50370276
Synonyms:
CHEMBL608370
Type:
Small organic molecule
Emp. Form.:
C15H24N6O11P2
Mol. Mass.:
526.3322
SMILES:
Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OCC2C[C@@H](O)CN2)[C@@H](O)[C@H]1O |r|
Structure:
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