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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50134783
Substrate
n/a
Meas. Tech.
ChEMBL_164500 (CHEMBL771477)
Ki
71000±n/a nM
Citation
 Wang, R; Harada, S; Mitsuya, H; Zemlicka, J Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer. J Med Chem 46:4799-802 (2003) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50134783
Synonyms:
6-amino-9-[(E)-(2-{[(1,2,3,3-tetrahydroxy-1,2,3-trioxidotriphosphanyl)oxy]methyl}cyclopropylidene)methyl]-9H-purine | CHEMBL145474
Type:
Small organic molecule
Emp. Form.:
C10H14N5O8P3
Mol. Mass.:
425.1681
SMILES:
Nc1ncnc2n(\C=C3/CC3COP(O)(=O)P(O)(=O)P(O)(O)=O)cnc12
Structure:
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