Reaction Details Report a problem with these data
Target
Carbonic anhydrase
Ligand
BDBM10857
Substrate
n/a
Meas. Tech.
ChEMBL_303239 (CHEMBL827204)
Ki
3930±n/a nM
Citation
 Zimmerman, S; Innocenti, A; Casini, A; Ferry, JG; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides. Bioorg Med Chem Lett 14:6001-6 (2004) [PubMed]  Article 
Target
Name:
Carbonic anhydrase
Synonyms:
CAH_METTT | CAM | Carbonic anhydrase | Gamma-carbonic anhydrase
Type:
Protein
Mol. Mass.:
26390.56
Organism:
Methanosarcina thermophila
Description:
P40881
Residue:
247
Sequence:
MMFNKQIFTILILSLSLALAGSGCISEGAEDNVAQEITVDEFSNIRENPVTPWNPEPSAPVIDPTAYIDPQASVIGEVTIGANVMVSPMASIRSDEGMPIFVGDRSNVQDGVVLHALETINEEGEPIEDNIVEVDGKEYAVYIGNNVSLAHQSQVHGPAAVGDDTFIGMQAFVFKSKVGNNCVLEPRSAAIGVTIPDGRYIPAGMVVTSQAEADKLPEVTDDYAYSHTNEAVVYVNVHLAEGYKETS
  
Inhibitor
Name:
BDBM10857
Synonyms:
4-aminobenzene-1-sulfonamide | CHEMBL21 | Sulfanilamide | aromatic sulfonamide compound 5 | aromatic/heteroaromatic sulfonamide 2 | halogenosulfanilamide deriv. 5a
Type:
Small organic molecule
Emp. Form.:
C6H8N2O2S
Mol. Mass.:
172.205
SMILES:
Nc1ccc(cc1)S(N)(=O)=O
Structure:
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