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Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50181844
Substrate
n/a
Meas. Tech.
ChEMBL_332071 (CHEMBL859603)
Ki
0.183000±n/a nM
Citation
 Becker, DP; Flynn, DL; Moormann, AE; Nosal, R; Villamil, CI; Loeffler, R; Gullikson, GW; Moummi, C; Yang, DC Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists. J Med Chem 49:1125-39 (2006) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43735.29
Organism:
GUINEA PIG
Description:
5-HT4 HTR4 GUINEA PIG::O70528
Residue:
388
Sequence:
MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
  
Inhibitor
Name:
BDBM50181844
Synonyms:
(1R,7aS)-hexahydro-1H-pyrrolizin-1-ylmethyl 4-amino-5-chloro-2-methoxybenzoate | CHEMBL201621
Type:
Small organic molecule
Emp. Form.:
C16H21ClN2O3
Mol. Mass.:
324.803
SMILES:
COc1cc(N)c(Cl)cc1C(=O)OC[C@@H]1CCN2CCC[C@@H]12
Structure:
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