Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50192105
Substrate
n/a
Meas. Tech.
ChEMBL_404137 (CHEMBL909747)
IC50
>200000±n/a nM
Citation
 Lazarova, TI; Jin, L; Rynkiewicz, M; Gorga, JC; Bibbins, F; Meyers, HV; Babine, R; Strickler, J Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa. Bioorg Med Chem Lett 16:5022-7 (2006) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50192105
Synonyms:
1-{[4-(dihydroxyboranyl)phenyl]methyl}guanidine; 2,2,2-trifluoroacetic acid | CHEMBL215135
Type:
Small organic molecule
Emp. Form.:
C8H12BN3O2
Mol. Mass.:
193.011
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6]-c1ccc(cc1)-[#5](-[#8])-[#8]
Structure:
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