Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50195509
Substrate
n/a
Meas. Tech.
ChEMBL_414848 (CHEMBL855029)
Ki
>1000±n/a nM
Citation
 Manera, C; Benetti, V; Castelli, MP; Cavallini, T; Lazzarotti, S; Pibiri, F; Saccomanni, G; Tuccinardi, T; Vannacci, A; Martinelli, A; Ferrarini, PL Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists. J Med Chem 49:5947-57 (2006) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_MOUSE | Cannabinoid CB1 receptor | Cannabinoid receptor | Cnr1
Type:
Enzyme
Mol. Mass.:
52842.52
Organism:
Mus musculus (Mouse)
Description:
P47746
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50195509
Synonyms:
4-hydroxy-N-(4-methylcyclohexyl)-1-(2-morpholin-4-ylethyl)-7-methyl-1,2,3,4-tetrahydro-1,8-naphthyridin-3-carboxamide | CHEMBL217247
Type:
Small organic molecule
Emp. Form.:
C23H36N4O3
Mol. Mass.:
416.5569
SMILES:
CC1CCC(CC1)NC(=O)C1CN(CCN2CCOCC2)c2nc(C)ccc2C1O |(31.74,-6.21,;30.4,-6.98,;30.4,-8.52,;29.06,-9.29,;27.73,-8.52,;27.73,-6.98,;29.06,-6.21,;26.4,-9.29,;25.06,-8.52,;25.06,-6.98,;23.73,-9.29,;23.73,-10.83,;22.4,-11.61,;22.4,-13.15,;23.73,-13.91,;23.73,-15.46,;25.06,-16.23,;25.06,-17.77,;23.73,-18.54,;22.4,-17.77,;22.4,-16.23,;21.06,-10.83,;19.73,-11.61,;18.4,-10.83,;17.06,-11.61,;18.4,-9.29,;19.73,-8.52,;21.06,-9.29,;22.4,-8.52,;22.4,-6.98,)|
Structure:
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