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Target
Kappa-type opioid receptor
Ligand
BDBM50045767
Substrate
n/a
Meas. Tech.
ChEMBL_422446 (CHEMBL909320)
Ki
17±n/a nM
Citation
 Le Bourdonnec, B; Goodman, AJ; Michaut, M; Ye, HF; Graczyk, TM; Belanger, S; Herbertz, T; Yap, GP; DeHaven, RN; Dolle, RE Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of mu-opioid receptor antagonists. J Med Chem 49:7278-89 (2006) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM50045767
Synonyms:
(+)-N-phenethyl trans-3(R),4(R)-dimethyl-4-(3-hydroxyphenyl)piperidine | 3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenol | 3-(3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenol | 3-(trans-3,4-dimethyl-1-phenethylpiperidin-4-yl)phenol | CHEMBL319536 | N-phenethyltrans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine
Type:
Small organic molecule
Emp. Form.:
C21H27NO
Mol. Mass.:
309.4452
SMILES:
C[C@H]1CN(CCc2ccccc2)CC[C@@]1(C)c1cccc(O)c1
Structure:
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