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Target
Beta-lactamase
Ligand
BDBM50202234
Substrate
n/a
Meas. Tech.
ChEMBL_433253 (CHEMBL914658)
Ki
5000±n/a nM
Citation
 Thomson, JM; Prati, F; Bethel, CR; Bonomo, RA Use of novel boronic acid transition state inhibitors to probe substrate affinity in SHV-type extended-spectrum beta-lactamases. Antimicrob Agents Chemother 51:1577-9 (2007) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
SHV-5 extended spectrum beta-lactamase
Type:
PROTEIN
Mol. Mass.:
31312.77
Organism:
Escherichia coli
Description:
ChEMBL_433253
Residue:
286
Sequence:
MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKNGASKRGARGIVALLGPNNKAERIVVIYLRDTPANMAERNQQIAGIGAALIEHWQR
  
Inhibitor
Name:
BDBM50202234
Synonyms:
(Z)-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)methylboronic acid | CHEMBL227452 | [(2-AMINO-ALPHA-METHOXYIMINO-4-THIAZOLYLACETYL)AMINO]METHYLBORONIC ACID
Type:
Small organic molecule
Emp. Form.:
C7H11BN4O4S
Mol. Mass.:
258.063
SMILES:
CO\N=C(/C(=O)NCB(O)O)c1csc(N)n1
Structure:
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