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Target
Beta-lactamase
Ligand
BDBM50202233
Substrate
n/a
Meas. Tech.
ChEMBL_433253 (CHEMBL914658)
Ki
360000±n/a nM
Citation
 Thomson, JM; Prati, F; Bethel, CR; Bonomo, RA Use of novel boronic acid transition state inhibitors to probe substrate affinity in SHV-type extended-spectrum beta-lactamases. Antimicrob Agents Chemother 51:1577-9 (2007) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
SHV-5 extended spectrum beta-lactamase
Type:
PROTEIN
Mol. Mass.:
31312.77
Organism:
Escherichia coli
Description:
ChEMBL_433253
Residue:
286
Sequence:
MRYIRLCIISLLATLPLAVHASPQPLEQIKQSESQLSGRVGMIEMDLASGRTLTAWRADERFPMMSTFKVVLCGAVLARVDAGDEQLERKIHYRQQDLVDYSPVSEKHLADGMTVGELCAAAITMSDNSAANLLLATVGGPAGLTAFLRQIGDNVTRLDRWETELNEALPGDARDTTTPASMAATLRKLLTSQRLSARSQRQLLQWMVDDRVAGPLIRSVLPAGWFIADKNGASKRGARGIVALLGPNNKAERIVVIYLRDTPANMAERNQQIAGIGAALIEHWQR
  
Inhibitor
Name:
BDBM50202233
Synonyms:
Acylglycineboronic acid, 5 | CHEMBL227673 | acetamidomethylboronic acid
Type:
Small organic molecule
Emp. Form.:
C3H8BNO3
Mol. Mass.:
116.912
SMILES:
CC(=O)NCB(O)O
Structure:
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