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Target
Heme oxygenase 1
Ligand
BDBM50183062
Substrate
n/a
Meas. Tech.
ChEMBL_435911 (CHEMBL905312)
IC50
4300±n/a nM
Citation
 Roman, G; Riley, JG; Vlahakis, JZ; Kinobe, RT; Brien, JF; Nakatsu, K; Szarek, WA Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring. Bioorg Med Chem 15:3225-34 (2007) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50183062
Synonyms:
1-((2-(2-(4-chlorophenyl)ethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | 1-((2-(4-chlorophenethyl)-1,3-dioxolan-2-yl)methyl)-1H-imidazole hydrochloride | 2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane hydrochloride | CHEMBL495072 | CHEMBL541899
Type:
Small organic molecule
Emp. Form.:
C15H17ClN2O2
Mol. Mass.:
292.761
SMILES:
Clc1ccc(CCC2(Cn3ccnc3)OCCO2)cc1
Structure:
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