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Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50213578
Substrate
n/a
Meas. Tech.
ChEMBL_436893 (CHEMBL905198)
Ki
288±n/a nM
Citation
 Chlon-Rzepa, G; Zmudzki, P; Zajdel, P; Bojarski, AJ; Duszynska, B; Nikiforuk, A; Tatarczynska, E; Pawlowski, M 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands. Bioorg Med Chem 15:5239-50 (2007) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50213578
Synonyms:
7-{3-[4-(3-chlorophenyl)-piperazin-1-yl]-propyl}-8-propoxy-1,3-dimethyl-3,7-dihydropurine-2,6-dione | CHEMBL229179
Type:
Small organic molecule
Emp. Form.:
C23H31ClN6O3
Mol. Mass.:
474.984
SMILES:
CCCOc1nc2n(C)c(=O)n(C)c(=O)c2n1CCCN1CCN(CC1)c1cccc(Cl)c1
Structure:
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