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Target
Beta-lactamase TEM
Ligand
BDBM50218934
Substrate
n/a
Meas. Tech.
ChEMBL_445224 (CHEMBL894371)
IC50
21±n/a nM
Citation
 Plantan, I; Selic, L; Mesar, T; Anderluh, PS; Oblak, M; Prezelj, A; Hesse, L; Andrejasic, M; Vilar, M; Turk, D; Kocijan, A; Prevec, T; Vilfan, G; Kocjan, D; Copar, A; Urleb, U; Solmajer, T 4-Substituted trinems as broad spectrum beta-lactamase inhibitors: structure-based design, synthesis, and biological activity. J Med Chem 50:4113-21 (2007) [PubMed]  Article 
Target
Name:
Beta-lactamase TEM
Synonyms:
BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla
Type:
Enzyme
Mol. Mass.:
31512.33
Organism:
Escherichia coli
Description:
P62593
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM50218934
Synonyms:
CHEMBL395017 | sodium (8S,9R)-10(E)-ethylidene-4(S)-(2'-fluoroethoxy)-11-oxo-1-azatricyclo[7.2.0.03, 8]undec-2-enecarboxylate
Type:
Small organic molecule
Emp. Form.:
C15H17FNO4
Mol. Mass.:
294.2987
SMILES:
C\C=C1/[C@H]2[C@H]3CCC[C@H](OCCF)C3=C(N2C1=O)C([O-])=O |c:14|
Structure:
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