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Target
Prothrombin
Ligand
BDBM50228418
Substrate
n/a
Meas. Tech.
ChEMBL_452529 (CHEMBL901753)
IC50
>100000±n/a nM
Citation
 Joossens, J; Ali, OM; El-Sayed, I; Surpateanu, G; Van der Veken, P; Lambeir, AM; Setyono-Han, B; Foekens, JA; Schneider, A; Schmalix, W; Haemers, A; Augustyns, K Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. J Med Chem 50:6638-46 (2007) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activated blood-coagulation factor II | Activation peptide fragment 1 | Activation peptide fragment 2 | Beta-thrombin | Blood-coagulation factor IIa | Coagulation factor II | E thrombin | F2 | Factor IIa | Fibrinogenase | Gamma-thrombin | Prothrombin | THRB_RAT | Thrombase | Thrombin | Thrombin heavy chain | Thrombin light chain | Thrombin-C | Thrombofort | Tropostasin
Type:
Protein
Mol. Mass.:
70413.05
Organism:
Rattus norvegicus
Description:
P18292
Residue:
617
Sequence:
MLHVRGLGLPGCLALAALASLVHSQHVFLAPQQALSLLQRVRRANSGFLEELRKGNLERECVEEQCSYEEAFEALESPQDTDVFWAKYTVCDSVRKPRETFMDCLEGRCAMDLGLNYHGNVSVTHTGIECQLWRSRYPHRPDINSTTHPGADLKENFCRNPDSSTSGPWCYTTDPTVRREECSIPVCGQEGRTTVKMTPRSRGSKENLSPPLGECLLERGRLYQGNLAVTTLGSPCLAWDSLPTKTLSKYQNFDPEVKLVQNFCRNPDRDEEGAWCFVAQQPGFEYCSLNYCDEAVGEENHDGDESIAGRTTDAEFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKELLDSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCILYPPWDKNFTENDLLVRIGKHSRTRYERNVEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFSDYIHPVCLPDKQTVTSLLQAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIRITDNMFCAGFKVNDTKRGDACEGDSGGPFVMKSPYNHRWYQMGIVSWGEGCDRNGKYGFYTHVFRLKRWMQKVIDQHR
  
Inhibitor
Name:
BDBM50228418
Synonyms:
CHEMBL393591 | methyl 1-(diphenoxyphosphoryl)-2-(4-guanidinophenyl)ethylcarbamate
Type:
Small organic molecule
Emp. Form.:
C23H25N4O5P
Mol. Mass.:
468.4422
SMILES:
[#6]-[#8]-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1
Structure:
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