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Target
Lanosterol synthase ERG7
Ligand
BDBM50195962
Substrate
n/a
Meas. Tech.
ChEMBL_452981 (CHEMBL902126)
IC50
1780±n/a nM
Citation
 Galli, U; Oliaro-Bosso, S; Taramino, S; Venegoni, S; Pastore, E; Tron, GC; Balliano, G; Viola, F; Sorba, G Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase. Bioorg Med Chem Lett 17:220-4 (2006) [PubMed]  Article 
Target
Name:
Lanosterol synthase ERG7
Synonyms:
ERG7 | ERG7_YEAST | Lanosterol synthase
Type:
PROTEIN
Mol. Mass.:
83460.43
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_956105
Residue:
731
Sequence:
MTEFYSDTIGLPKTDPRLWRLRTDELGRESWEYLTPQQAANDPPSTFTQWLLQDPKFPQPHPERNKHSPDFSAFDACHNGASFFKLLQEPDSGIFPCQYKGPMFMTIGYVAVNYIAGIEIPEHERIELIRYIVNTAHPVDGGWGLHSVDKSTVFGTVLNYVILRLLGLPKDHPVCAKARSTLLRLGGAIGSPHWGKIWLSALNLYKWEGVNPAPPETWLLPYSLPMHPGRWWVHTRGVYIPVSYLSLVKFSCPMTPLLEELRNEIYTKPFDKINFSKNRNTVCGVDLYYPHSTTLNIANSLVVFYEKYLRNRFIYSLSKKKVYDLIKTELQNTDSLCIAPVNQAFCALVTLIEEGVDSEAFQRLQYRFKDALFHGPQGMTIMGTNGVQTWDCAFAIQYFFVAGLAERPEFYNTIVSAYKFLCHAQFDTECVPGSYRDKRKGAWGFSTKTQGYTVADCTAEAIKAIIMVKNSPVFSEVHHMISSERLFEGIDVLLNLQNIGSFEYGSFATYEKIKAPLAMETLNPAEVFGNIMVEYPYVECTDSSVLGLTYFHKYFDYRKEEIRTRIRIAIEFIKKSQLPDGSWYGSWGICFTYAGMFALEALHTVGETYENSSTVRKGCDFLVSKQMKDGGWGESMKSSELHSYVDSEKSLVVQTAWALIALLFAEYPNKEVIDRGIDLLKNRQEESGEWKFESVEGVFNHSCAIEYPSYRFLFPIKALGMYSRAYETHTL
  
Inhibitor
Name:
BDBM50195962
Synonyms:
(4E,8E)-10-(hexyloxy)-N,N,4,8-tetramethyldeca-4,8-dien-1-amine | CHEMBL246993
Type:
Small organic molecule
Emp. Form.:
C20H39NO
Mol. Mass.:
309.5298
SMILES:
CCCCCCOC\C=C(/C)CC\C=C(/C)CCCN(C)C
Structure:
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