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Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50201221
Substrate
n/a
Meas. Tech.
ChEMBL_453855 (CHEMBL885857)
IC50
900±n/a nM
Citation
 Sheppeck, JE; Tebben, A; Gilmore, JL; Yang, A; Wasserman, ZR; Decicco, CP; Duan, JJ A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE. Bioorg Med Chem Lett 17:1408-12 (2007) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme
Type:
Metalloprotease
Mol. Mass.:
12197.99
Organism:
Sus scrofa (pig)
Description:
Partially purified TACE was obtained from porcine spleen.
Residue:
112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
  
Inhibitor
Name:
BDBM50201221
Synonyms:
CHEMBL397852 | N-((5S,9R)-2,4-dioxo-1,3,7-triaza-spiro[4.4]non-9-yl)-4-(2-methyl-quinolin-4-ylmethoxy)-benzamide
Type:
Small organic molecule
Emp. Form.:
C24H23N5O4
Mol. Mass.:
445.4705
SMILES:
Cc1cc(COc2ccc(cc2)C(=O)N[C@@H]2CNC[C@]22NC(=O)NC2=O)c2ccccc2n1
Structure:
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