Reaction Details Report a problem with these data
Target
Macrophage migration inhibitory factor
Ligand
BDBM50373157
Substrate
n/a
Meas. Tech.
ChEMBL_467033 (CHEMBL932723)
IC50
4000±n/a nM
Citation
 Crichlow, GV; Cheng, KF; Dabideen, D; Ochani, M; Aljabari, B; Pavlov, VA; Miller, EJ; Lolis, E; Al-Abed, Y Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor. J Biol Chem 282:23089-95 (2007) [PubMed]  Article 
Target
Name:
Macrophage migration inhibitory factor
Synonyms:
GIF | GLIF | Glycosylation-inhibiting factor | L-dopachrome isomerase | L-dopachrome tautomerase | MIF | MIF/CD74 (Macrophage migration inhibitory factor and HLA-DR antigens-associated invariant chain) | MIF_HUMAN | MMIF | Macrophage migration inhibitory factor | Macrophage migration inhibitory factor (MIF) | Phenylpyruvate tautomerase
Type:
Enzyme
Mol. Mass.:
12478.18
Organism:
Homo sapiens (Human)
Description:
P14174
Residue:
115
Sequence:
MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
  
Inhibitor
Name:
BDBM50373157
Synonyms:
CHEMBL257350
Type:
Small organic molecule
Emp. Form.:
C13H15NO3
Mol. Mass.:
233.2631
SMILES:
Oc1ccc(C=NOC(=O)C2CCCC2)cc1 |w:5.4|
Structure:
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