Reaction Details Report a problem with these data
Target
Segment polarity protein dishevelled homolog DVL-3
Ligand
BDBM50373848
Substrate
n/a
Meas. Tech.
ChEMBL_468589 (CHEMBL931112)
IC50
23000±n/a nM
Citation
 Mahindroo, N; Punchihewa, C; Bail, AM; Fujii, N Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity. Bioorg Med Chem Lett 18:946-9 (2008) [PubMed]  Article 
Target
Name:
Segment polarity protein dishevelled homolog DVL-3
Synonyms:
DSH homolog 3 | DVL3 | DVL3_HUMAN | Dishevelled-3 | KIAA0208
Type:
PROTEIN
Mol. Mass.:
78056.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_468589
Residue:
716
Sequence:
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEISDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPHAGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLMSSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAAWVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMASPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHTVNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQYPPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGGSGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPPLYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM
  
Inhibitor
Name:
BDBM50373848
Synonyms:
CHEMBL255779
Type:
Small organic molecule
Emp. Form.:
C25H28N2O3
Mol. Mass.:
404.5014
SMILES:
Cc1cc2[nH]c(C(=O)NC3CCCCC3)c(CCc3ccccc3)c2cc1C(O)=O
Structure:
Search PDB for entries with ligand similarity: