Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 3
Ligand
BDBM94737
Substrate
n/a
Meas. Tech.
ChEMBL_470258 (CHEMBL950213)
IC50
1100±n/a nM
Citation
 Hayes, ME; Breinlinger, EC; Wallace, GA; Grongsaard, P; Miao, W; McPherson, MJ; Stoffel, RH; Green, DW; Roth, GP Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3. Bioorg Med Chem Lett 18:2414-9 (2008) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 3
Synonyms:
AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40665.65
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
368
Sequence:
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
  
Inhibitor
Name:
BDBM94737
Synonyms:
1-(4-chlorophenyl)-2-(2-imino-3-propyl-1-benzimidazolyl)ethanone;hydrobromide | 1-(4-chlorophenyl)-2-(2-imino-3-propyl-2,3-dihydro-1H-benzimidazol-1-yl)ethanone hydrobromide | 1-(4-chlorophenyl)-2-(2-imino-3-propyl-benzimidazol-1-yl)ethanone;hydrobromide | 1-(4-chlorophenyl)-2-(2-imino-3-propylbenzimidazol-1-yl)ethanone;hydrobromide | 2-(2-azanylidene-3-propyl-benzimidazol-1-yl)-1-(4-chlorophenyl)ethanone;hydrobromide | CHEMBL272060 | MLS001164394 | SMR000496606 | cid_2851386
Type:
Small organic molecule
Emp. Form.:
C18H18ClN3O
Mol. Mass.:
327.808
SMILES:
CCCn1c2ccccc2n(CC(=O)c2ccc(Cl)cc2)c1=N
Structure:
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